Parkinson’s
disease (PD) belongs to a group of neurodegenerative conditions called motor
system disorders, which are the result of the loss of dopamine-producing brain
cells. The four primary symptoms of PD are tremor, or trembling in hands, arms,
legs, jaw, and face rigidity, or stiffness of the limbs and trunk bradykinesia,
or slowness of movement, postural instability, or impaired balance and
coordination 1.

 

The
prevalence
of the disease ranges from 41 people per 100,000 in the fourth decade of life
to more than 1,900 people per 100,000 among those 80 and older 2.

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Patients
are usually treated with Levodopa, COMT Inhibitors, Dopamine Agonists,
Non-Dopaminergic Therapy, etc 3. Therefore, auditing of prescriptions related
to the disease is essential to increase the therapeutic efficacy and to
decrease the side effects & also to provide feedback to the
prescribers. The main aim of this drug utilization study is to facilitate
rational drug use and knowing the efficacy of each one of them 4.

 

Quality
of Life (QoL) is a multi-dimensional construct, which consists of at least
three broad domains: physical, mental and social. In the field of medicine,
researchers and physicians have often used health-related quality of life
concept, which specifically focuses on the impact of an illness and/or
treatment on patients’ perception of their status of health and on subjective
well-being or satisfaction with life 5.

 

Therefore,
evaluation of the severity of any disease should include not only the clinical
factors but also the psychological & social factors pertaining with the
patient. Parkinson’s Disease has a profound negative impact on the Quality of
Life (QoL) as pointed out by numerous studies, patients suffer from fatigue,
dementia, emotional problems, sleep disorders, difficulty in speech and
balance, depression, diminished cognitive functions and several other lifestyle
changes 6.

 

For
analysis of QoL, some questionnaires were developed exclusively for patients with Parkinson’s disease (PD).
The best known are two scales, Quality of Life
Questionnaire (PDQL). Martinez-Martin believes
that the quality Parkinson’s Disease. Questionnaire
(PDQ-39) and Parkinson’s Disease of life
scales are more useful than other scales in
evaluating the results of rehabilitation and drug
treatment of Parkinson’s disease or neurosurgery 7. Hence, Parkinson’s
Disease Questionnaire- 39 is being used in this study.